A 27 year old man is referred to clinic with easy bruising and epistaxis. Examination reveals numerous large ecchymoses as well as a palpable mass in the left upper quadrant consistent with splenomegaly. Blood results Hb 13 g/dL WC 3.2 Plt 78 Blood film: leukoerythroblastic with tear drop poikilocytes and large platelets PT 11.4 APTT 28.3 PFA 100 >300s Platelet aggregometry ADP - reduced aggregation Collagen - reduced aggregation Ristocetin - normal Arachdonic acid - normal Platelet nucleotides - normal |
Practice Questions > Clotting >