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Question 9 Answer 2

What other coagulation factor should now be measured?

  • Factor VIII levels to exclude combined factor V and VIII deficiency


How would manage this patient?

  1. Virally inactivated FFP to raise the FV level above 15 iu/dL (probably 20-25 mL/kg).  This should be repeated in order to maintain the factor V level above 15 iu/dL until the patient is stable.  
  2. If this fails platelet transfusion could be used to deliver higher levels of FV locally.
  3. Fluid balance may be problematic with relatively large volumes of FFP being given a small baby.